Asmik Grigorian was born in Vilnius, 1981, in the family of Irena Milkevičiūtė and Geghamas Grigorianas, both famous singers. She attended the The National M. K. Čiurlionis School of Art learning to play piano and choir conducting.

In 1999 she enrolled in the Lithuanian Academy of Music and Theatre studying singing. She received a Master’s degree studying in the class of professor Irena Milkevičiūtė. She has received master classes from G. Grigorian, V. Prudnikovas, B. Maisuradzė, A. Pagliazzi, Mirella Freni.

Asmik Grigorian performed with the Vilnius Quartet and Quintet, National and State symphony orchestras, Vilnius and Moscow Kremlin chamber orchestras as well as the Šv. Kristoforas orchestra.

In the 2004 Vilnius Festival, A. Grigorian sang in the premiere of Feliksas Bajoras’s 5th symphony for voice and orchestra. It was performed together with the National Symphony Orchestra conducted by Robertas Šervenikas.

She toured Manchester with the St. Petersburg Marinski theatre, performing the part of Prilepa in Pyotr Ilyich Tchaikovsky’s opera The Queen of Spades (conductor G. Woseda). She worked with the theatre again, performing the part of Desdemona in G. Verdi’s opera Otello, a role she later reprised at the Batumis opera theatre (2004). She has appeared in the Vilnius, Pažaislis, Gaida, Šv. Kristoforo and St. Petersburg Palace festivals.

The singer has worked with many conductors, including: V. Gergyev, V. Petrenko, Gintaras Rinkevičius, Juozas Domarkas, G. Woseda, M. Soustrat, Donatas Katkus, Vytautas Lukočius, Modestas Pitrėnas, Martynas Staškus, Julius Geniušas, M. Brabbins, H. Nanasi, M. Tatarnikov, K. Durgarian, Julian Reynolds, Tadeusz Wojciechowski, Rolf Beck. She has also worked with some famous directors: D.Ibelhauptaitė, B.Cosky, I. Kerkhof, J. Miller, A. Zagars, R. Wilson, K. Wuss, P. Konwinchny, C. Loy, K. Mondriusko, I van Hove, V. Barkhatov.

In Kristiansand (Norway, 2005 09 01) she performed as Donna Anna in W. A. Mozart’s opera Don Giovanni (directed by Sir J. Miller, conducted by M. Soustrat). In 2005 12 31 she debuted at the Lithuanian National Opera and Ballet Theatre singing the part of Violetta in G. Verdi’s opera “La traviata”. She later performed in Kaunas, Klaipėda, and Ryga and in 2006 she debuted in the legendary Wigmore Hall, performing various arias from operas “Madame Butterfly”, “Turandot” and others.

Since 2006 she has appeared consistently at the The Latvian National Opera House, performing more than 10 parts: Susan and La Contessa Almaviva in Mozart’s The Marriage of Figaro, Donna Elvira in Don Giovanni, the water nymph in A. Dvorak’s Rusalka, Micaela in G. Bizet’s opera Carmen, Violetta Valery in G. Verdi’s opera La Traviata, Alcina in G. F. Handel's opera Alcina.

Her latest performances include Liza in Tchaikovsky’s The Queen of Spades, Euridice in Ch. W. Von Gluck’s Orfeo ed Euridice, Mimì and Musetta in G. Puccini's La bohème, Pamina in Mozart’s The Magic Flute, the baker in Stephen Sondheim’s Sweeney Todd, Violetta Valery in La Traviata.

Asmik’s repertoire comprises of more than 40 roles and 20 large concerts, although at the moment she has been increasingly performing lirico-spinto soprano roles.

She has been awarded the Golden Stage Cross twice, in 2005 for her debut as Violetta and in 2010 for her performance as Lovet in the operetta/musical category.

In July 2018 Lithuanian opera singer Asmik Grigorian triumphed at the Salzburger Festspiele, one of the world's leading classical music and performing arts festivals, performing Salome's role in Richard Strauss's "Salome", directed by famous Italian director Romeo Castellucci.

Having conquered Salzburg, Asmik Grigorian has already been invited to perform as Salome at the New York Metropolitan Opera. In the next three years, she will also sing main parts at Milan's La Scala, London's Royal Opera House, Paris‘s Bastille and Vienna‘s State Opera. Next February the soloist will appear to the Vilnius City Opera audience in the premiere of „The Queen of Spades“.